Genentech’s new combo pipelines

atezolizumab + entinostat (HDAC1,3 inhibitor)

atezolizumab + CD47

CD47

  • Integrin associated protein
  • immunoglobulin superfamily
  • immune and angiogenic response
  • over expressed in cancer cells
  • anti-CD47 antibody – cancer cell phagocytosis by macrophage & initiated anti tumor T-cell response

CD47TumAndImmunoFig5

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